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Article

Human T-cell leukemia virus I tax protein sensitizes p53-mutant cells to DNA damage.

Cancer research - 15 Jun 2008

Mihaylova Valia T, Green Allison M, Khurgel Moshe, Semmes Oliver J, Kupfer Gary M

Abstract excerpt

Mutations in p53 are a common cause of resistance of cancers to standard chemotherapy and, thus, treatment failure. Reports have shown that Tax, a human T-cell leukemia virus type I encoded protein that has been associated with genomic instability and perturbation of transcription and cell cycle, sensitizes HeLa cells to UV treatment. The extent to which Tax can sensitize cells and the mechanism by which it...

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Identifiers

PMID: 18559532
DOI: 10.1158/0008-5472.CAN-07-5070
PMCID: PMC5939382

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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Human T-cell leukemia virus I tax protein sensitizes p53-mutant cells to DNA damage.PMID 18559532Read ↗

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P53 facilitates degradation of human T-cell leukaemia virus type I Tax-binding protein through a proteasome-dependent pathway.Semantic proximity Read ↗

A novel NF-kappaB pathway involving IKKbeta and p65/RelA Ser-536 phosphorylation results in p53 Inhibition in the absence of NF-kappaB transcriptional activity.Semantic proximity Read ↗

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