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Article

A functionally defective allele of TAP1 results in loss of MHC class I antigen presentation in a human lung cancer.

Nature genetics - 1 Jun 1996

Chen H L, Gabrilovich D, Tampé R, Girgis K R, Nadaf S, Carbone D P

Abstract excerpt

Tumours express a variety of novel epitopes which represent potential immune targets, and thus clinically evident tumours are thought to have effectively avoided immune recognition and elimination. Transporters associated with antigen presentation (TAP) are thought to be responsible for conveying intracellular peptides into the endoplasmic reticulum for complex formation with class I MHC and subsequent...

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Source

Identifiers

PMID: 8640228
DOI: 10.1038/ng0696-210

Genes

TAP1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

A functionally defective allele of TAP1 results in loss of MHC class I antigen presentation in a human lung cancer.PMID 8640228Read ↗

Loss of antigen-presenting molecules (MHC class I and TAP-1) in lung cancerSemantic proximity Read ↗

TAP expression provides a general method for improving the recognition of malignant cells in vivo.Semantic proximity Read ↗

The Transporter Associated With Antigen Processing (TAP): Structural Integrity, Expression, Function, and Its Clinical RelevanceSemantic proximity Read ↗

Transporter associated with antigen processing 1 (TAP1) expression and prognostic analysis in breast, lung, liver, and ovarian cancer.Semantic proximity Read ↗

Peptide transport in human lymphoblastoid and tumor cells: effect of transporter associated with antigen presentation (TAP) polymorphism.Semantic proximity Read ↗

Immune escape of melanoma: first evidence of structural alterations in two distinct components of the MHC class I antigen processing pathway.Semantic proximity Read ↗

A novel mutation in the TAP2 gene in bare lymphocyte syndrome: association with metastatic cutaneous squamous cell carcinoma.Semantic proximity Read ↗

The association of TAP polymorphisms with non-small-cell lung cancer in the Han Chinese population.Semantic proximity Read ↗

Identification of mechanisms underlying transporter associated with antigen processing deficiency in metastatic murine carcinomas.Semantic proximity Read ↗

Functional deficiencies of components of the MHC class I antigen pathway in human tumors of epithelial origin.Semantic proximity Read ↗

Homozygous human TAP peptide transporter mutation in HLA class I deficiency.Semantic proximity Read ↗

Structure of the ABC ATPase domain of human TAP1, the transporter associated with antigen processingSemantic proximity Read ↗

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