Article
In vitro mutations in dihydrofolate reductase that confer resistance to methotrexate: potential for clinical application.
Human mutation - 1 Jan 1998
Blakley R L, Sorrentino B P
Abstract excerpt
Mammalian cells cultured in the presence of the chemotherapeutic agent, methotrexate, develop resistance to this drug. Sometimes this is due to mutations in the gene for dihydrofolate reductase, the primary target of methotrexate. However, it has not been possible to link such polymorphism to resistance of neoplastic disease to therapy with methotrexate. Nevertheless, interest in this possibility lead to the...
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