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Article

Increasing methotrexate resistance by combination of active-site mutations in human dihydrofolate reductase.

Journal of molecular biology - 26 Oct 2007

Volpato Jordan P, Fossati Elena, Pelletier Joelle N

Abstract excerpt

Methotrexate-resistant forms of human dihydrofolate reductase have the potential to protect healthy cells from the toxicity of methotrexate (MTX), to improve prognosis during cancer therapy. It has been shown that synergistic MTX-resistance can be obtained by combining two active-site mutations that independently confer weak MTX-resistance. In order to obtain more highly MTX-resistant human dihydrofolate...

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Source

Identifiers

PMID: 17868689
DOI: 10.1016/j.jmb.2007.07.076

Genes

DHFR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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