Article
Mutations leading to antifolate resistance in Chinese hamster ovary cells after exposure to the alkylating agent ethylmethanesulfonate.
Molecular pharmacology - 1 Jul 1993
Fanin R, Banerjee D, Volkenandt M, Waltham M, Li W W, Dicker A P, Schweitzer B I, Bertino J R
Abstract excerpt
Chinese hamster ovary cells with a single allele for dihydrofolate reductase were used as a model system to study the effect of exposure to an alkylating agent, ethylmethanesulfonate, on rates and types of mutations at the dihydrofolate reductase locus leading to antifolate resistance. After overnight exposure to 400 micrograms/ml ethylmethanesulfonate, cells were allowed to recover for 3 days, and resistant...
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