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Article

Molecular mechanisms of resistance to antifolates, a review.

Acta biochimica Polonica - 1 Jan 1995

Banerjee D, Ercikan-Abali E, Waltham M, Schnieders B, Hochhauser D, Li W W, Fan J, Gorlick R, Goker E, Bertino J R

Abstract excerpt

Methotrexate (MTX) is a clinically important antifolate that has been used in combination with other chemotherapeutic agents in the treatment of malignancies including acute lymphocytic leukemia, osteosarcoma, carcinomas of the breast, head and neck, choriocarcinoma and non-Hodgkin's lymphoma. The primary target of MTX is the enzyme dihydrofolate reductase (DHFR) which catalyzes the reduction of folate and...

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Source

Identifiers

PMID: 8852336

Genes

DHFR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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