Article
Mutations of human dihydrofolate reductase causing decreased inhibition by methotrexate.
Advances in experimental medicine and biology - 1 Jan 1993
Blakley R L, Appleman J R, Chunduru S K, Nakano T, Lewis W S, Harris S E
Abstract excerpt
No abstract is available from the source.
Topics
- Amino Acid Sequence
- Animals
- Binding Sites
- Cricetinae
- Escherichia coli
- Folic Acid
- Folic Acid Antagonists
- Genetic Variation
- Humans
- Kinetics
- Methotrexate
- Mice
- Mutagenesis, Site-Directed
- Point Mutation
- Recombinant Proteins
- Tetrahydrofolate Dehydrogenase
