Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Simian virus 40 large T antigen targets the spindle assembly checkpoint protein Bub1

19 Jan 2004

Abstract excerpt

The mitotic spindle checkpoint protein Bub1 has been found to be mutated at low frequency in certain human cancers characterized by aneuploidy. Simian virus 40 large T antigen efficiently immortalizes rodent cells and occasionally transforms them to tumorigenicity. T antigen can also cause genomic instability, inducing chromosomal aberrations and aneuploidy. Here, we report an interaction between Bub1 and T...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Chromosomal and Genetic Variations
Share to Microtubule and mitosis dynamics
Share to Polyomavirus and related diseases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 14732683
DOI: 10.1073/pnas.0308006100

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Simian virus 40 large T antigen targets the spindle assembly checkpoint protein Bub1PMID 14732683Read ↗

Simian Virus 40 Large T Antigen Disrupts Genome Integrity and Activates a DNA Damage Response via Bub1 BindingSemantic proximity Read ↗

Aurora B hyperactivation by Bub1 overexpression promotes chromosome missegregationSemantic proximity Read ↗

Multiple DNA Damage Signaling and Repair Pathways Deregulated by Simian Virus 40 Large T AntigenSemantic proximity Read ↗

Bub1 overexpression induces aneuploidy and tumor formation through Aurora B kinase hyperactivationSemantic proximity Read ↗

Bub1: Escapades in a Cellular WorldSemantic proximity Read ↗

BubR1 kinase: protection against aneuploidy and premature aging.Semantic proximity Read ↗

Large T Antigens of Polyomaviruses: Amazing Molecular MachinesSemantic proximity Read ↗

Simian virus 40 large T antigen affects the Saccharomyces cerevisiae cell cycle and interacts with p34CDC28.Semantic proximity Read ↗

Increased expression of BubR1 protects against aneuploidy and cancer and extends healthy lifespan.Semantic proximity Read ↗

Aneuploidy in health, disease, and agingSemantic proximity Read ↗

A dominant interfering Bub1 mutant is insufficient to induce or alter thymic tumorigenesis in vivo, even in a sensitized genetic background.Semantic proximity Read ↗

Cyclin B1 and Other Cyclins as Tumor Antigens in Immunosurveillance and Immunotherapy of CancerSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.