Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Identification of mutations in p53 that affect its binding to SV40 large T antigen by using the yeast two-hybrid system.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Jul 1993

Li B, Fields S

Abstract excerpt

The tumor suppressor p53 protein binds to the products of several viral oncogenes, including SV40 large T antigen. We reconstructed the p53-T antigen interaction in the yeast two-hybrid system, a genetic assay that uses the reconstitution of the activity of a transcriptional activator to detect protein-protein interactions. Using mutants of T antigen known to be defective in binding to p53, we demonstrate that...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amino Acid Sequence
Share to Genes, p53

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Molecular Sequence Data

Share to Mutation

Share to Protein Binding

Share to Saccharomyces cerevisiae

Share to Tumor Suppressor Protein p53

Source

Identifiers

PMID: 8344494
DOI: 10.1096/fasebj.7.10.8344494

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Identification of mutations in p53 that affect its binding to SV40 large T antigen by using the yeast two-hybrid system.PMID 8344494Read ↗

Identification of partial loss of function p53 gene mutations utilizing a yeast-based functional assay.Semantic proximity Read ↗

Functional analysis of p53 tumor suppressor in yeast.Semantic proximity Read ↗

Binding of cellular proteins to a conformational domain of tumor suppressor protein p53.Semantic proximity Read ↗

Screening the p53 status of human cell lines using a yeast functional assay.Semantic proximity Read ↗

Conformational shifts propagate from the oligomerization domain of p53 to its tetrameric DNA binding domain and restore DNA binding to select p53 mutants.Semantic proximity Read ↗

Mutant p53 proteins have diverse intracellular abilities to oligomerize and activate transcription.Semantic proximity Read ↗

Mammalian p53 can function as a transcription factor in yeastSemantic proximity Read ↗

Mutation detection by a two-hybrid assay.Semantic proximity Read ↗

Diversity of human p53 mutants revealed by complex formation to SV40 T antigen.Semantic proximity Read ↗

Mutagenesis of a functional chimeric gene in yeast identifies mutations in the simian virus 40 large T antigen J domain.Semantic proximity Read ↗

Identification of SV40 T-antigen mutants that alter T-antigen-induced chromosome damage in human fibroblasts.Semantic proximity Read ↗

New Insights into the Mechanism of Inhibition of p53 by Simian Virus 40 Large T AntigenSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.