Transformation and radiosensitivity of human diploid skin fibroblasts transfected with SV40 T-antigen mutants defective in RB and P53 binding domains.

doi:10.1080/09553009214552341

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Article

Transformation and radiosensitivity of human diploid skin fibroblasts transfected with SV40 T-antigen mutants defective in RB and P53 binding domains.

International journal of radiation biology - 1 Oct 1992

Su L N, Little J B

Abstract excerpt

A series of human diploid fibroblast cell clones were developed by DNA transfection with either wild-type SV40 T-antigen (SV40 T) or T-antigen mutants defective in its various functional domains. Cell clones expressing the wild-type SV40 T were significantly radioresistant as compared with clones transfected with the neo gene only (D0 = 192 +/- 13 vs 127 +/- 19). This radioresistance persisted in post-crisis,...

Topics

Antigens, Polyomavirus Transforming
Cell Adhesion
Cell Line
Cell Survival
Cell Transformation, Viral
Colony-Forming Units Assay
Diploidy
Fibroblasts
Genes, Retinoblastoma
Genes, p53
Humans

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Infant, Newborn

Male

Mutation

Radiation Tolerance

Skin

Transfection

Source

Open in PubMed

Identifiers

PMID: 1357059
DOI: 10.1080/09553009214552341

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1357059-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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