Induction of tetraploid DNA content by mutant simian virus 40 T antigen that has reduced complex formation with p53.

doi:10.1002/(SICI)1097-0320(19960201)23:2<126::AID-CYTO6>3.0.CO;2-I

Back to search

Article

Induction of tetraploid DNA content by mutant simian virus 40 T antigen that has reduced complex formation with p53.

Cytometry - 1 Feb 1996

Lehman J M, Perry M B, Laffin J

Abstract excerpt

The 402 mutants (DE, DH, DN) of simian virus (SV) 40 form reduced levels of p53-T antigen complexes or no complexes in lytically infected cells (CV-1 cells) relative to wild-type (wt) virus when assayed by immunoprecipitation. When CV-1 cells were infected with the 402 mutants, the cells were ind...

Topics

Antigens, Polyomavirus Transforming
Cell Cycle
DNA, Viral
Mutation
Ploidies
Tumor Suppressor Protein p53

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.