Article
Sanpodo and Notch act in opposition to Numb to distinguish sibling neuron fates in the Drosophila CNS.
Development (Cambridge, England) - 1 May 1998
Skeath J B, Doe C Q
Abstract excerpt
In Drosophila, most neuronal siblings have different fates ('A/B'). Here we demonstrate that mutations in sanpodo, a tropomodulin actin-binding protein homologue, equalize a diverse array of sibling neuron fates ('B/B'). Loss of Notch signaling gives the same phenotype, whereas loss of numb gives...
Topics
- Animals
- Carrier Proteins
- Cell Lineage
- Central Nervous System
- Drosophila
- Drosophila Proteins
- Epistasis, Genetic
- Genes, Insect
- Insect Proteins
- Juvenile Hormones
- Membrane Proteins
- Microfilament Proteins
- Mutagenesis
- Mutation
- Neurons
- Nuclear Proteins
- Phenotype
- Receptors, Notch