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Article

Cell fate determination. When is a determinant a determinant?

Current biology : CB - 1 May 1994

Cohen S, Hyman A A

Abstract excerpt

The Numb protein, which is asymmetrically distributed during certain cell divisions in the nervous system of Drosophila, may have a role in determining the developmental fates of the daughter cells.

Topics

Animals
Cell Division
Drosophila
Drosophila Proteins
Embryonic and Fetal Development
Genes, Insect
Juvenile Hormones
Mutation
Stem Cells

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 7922356
DOI: 10.1016/s0960-9822(00)00091-9

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7922356-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Click a neighbor to travelStep 1 · 12 closest

Cell fate determination. When is a determinant a determinant?PMID 7922356Read ↗

Bazooka recruits Inscuteable to orient asymmetric cell divisions in Drosophila neuroblasts.Semantic proximity Read ↗

Notch regulates numb: integration of conditional and autonomous cell fate specification.Semantic proximity Read ↗

Localization-dependent and -independent roles of numb contribute to cell-fate specification in Drosophila.Semantic proximity Read ↗

Binary sibling neuronal cell fate decisions in the Drosophila embryonic central nervous system are nonstochastic and require inscuteable-mediated asymmetry of ganglion mother cells.Semantic proximity Read ↗

The Multitasker Protein: A Look at the Multiple Capabilities of NUMBSemantic proximity Read ↗

Neural cell fate in rca1 and cycA mutants: the roles of intrinsic and extrinsic factors in asymmetric division in the Drosophila central nervous system.Semantic proximity Read ↗

Sanpodo and Notch act in opposition to Numb to distinguish sibling neuron fates in the Drosophila CNS.Semantic proximity Read ↗

The enigma of the numb-Notch relationship during mammalian embryogenesis.Semantic proximity Read ↗

Mother-daughter precursor cell fate transformation after Cdc2 down-regulation in the Drosophila bristle lineage.Semantic proximity Read ↗

At the nexus between pattern formation and cell-type specification: the generation of individual neuroblast fates in the Drosophila embryonic central nervous system.Semantic proximity Read ↗

Bazooka is required for localization of determinants and controlling proliferation in the sensory organ precursor cell lineage in Drosophila.Semantic proximity Read ↗

Asymmetric localization of a mammalian numb homolog during mouse cortical neurogenesis.Semantic proximity Read ↗

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