Article
Identification and characterization of multiple HLA-A24-restricted HIV-1 CTL epitopes: strong epitopes are derived from V regions of HIV-1.
Journal of immunology (Baltimore, Md. : 1950) - 15 Dec 1997
Ikeda-Moore Y, Tomiyama H, Miwa K, Oka S, Iwamoto A, Kaneko Y, Takiguchi M
Abstract excerpt
HIV-1-specific CTL has a crucial role in the elimination of the virus. However, a restricted number of common HLA class I alleles has been studied for their presentation of HIV-1 CTL epitopes. We have attempted to identify HIV-1 CTL epitopes presented by HLA-A*2402 using reverse immunogenetics. F...
Topics
- Alleles
- Clone Cells
- Cytotoxicity, Immunologic
- Epitopes, T-Lymphocyte
- HIV Envelope Protein gp120
- HIV Infections
- HIV-1
- HLA-A Antigens
- HLA-A24 Antigen
- Humans
- Lymphocyte Activation
- Mutation
- Peptides
- Protein Binding
- T-Lymphocytes, Cytotoxic