Article
Identification of hepatitis B virus-specific CTL epitopes presented by HLA-A*2402, the most common HLA class I allele in East Asia.
Journal of hepatology - 1 Jun 2001
Sobao Y, Sugi K, Tomiyama H, Saito S, Fujiyama S, Morimoto M, Hasuike S, Tsubouchi H, Tanaka K, Takiguch M
Abstract excerpt
BACKGROUND/AIMS: The aim of this study was to identify and characterize hepatitis B virus (HBV)-specific cytotoxic T lymphocytes (CTL) epitopes presented by human leukocyte antigen (HLA)-A*2402, most common HLA class I allele in East Asia. METHODS: HLA-A*2402-restricted CTL epitopes were identified by reverse immunogenetics. Immunogenecity of these epitopes was investigated using peripheral blood mononuclear cell...
Topics
- Acute Disease
- Alleles
- Antigen Presentation
- Clone Cells
- Asia, Eastern
- HLA-A Antigens
- HLA-A24 Antigen
- Hepatitis B
- Hepatitis B Antigens
- Hepatitis B, Chronic
- Humans
- Immunodominant Epitopes
- Leukocytes, Mononuclear