Article
The effect of epitope variation on the profile of cytotoxic T lymphocyte responses to the HIV envelope glycoprotein.
International immunology - 1 Dec 1998
Kmieciak D, Bednarek I, Takiguchi M, Wasik T J, Bratosiewicz J, Wierzbicki A, Teppler H, Pientka J, Hsu S H, Kaneko Y, Kozbor D
Abstract excerpt
To address the relationship between viral and host factors during HIV infection, we analyzed the effect of viral mutations on T cell responses in seropositive, asymptomatic HLA-A2+ individuals using four envelope (env)-specific peptides with the HLA-A*0201 binding motif. We showed that the natura...
Topics
- Adult
- CD28 Antigens
- Cell Line
- Cytotoxicity, Immunologic
- Epitopes, T-Lymphocyte
- Genetic Variation
- HIV Envelope Protein gp120
- HLA-A2 Antigen
- Humans
- Lymphocyte Activation
- Prospective Studies