Article
The effect of epitope variation on the profile of cytotoxic T lymphocyte responses to the HIV envelope glycoprotein.
International immunology - 1 Dec 1998
Kmieciak D, Bednarek I, Takiguchi M, Wasik T J, Bratosiewicz J, Wierzbicki A, Teppler H, Pientka J, Hsu S H, Kaneko Y, Kozbor D
Abstract excerpt
To address the relationship between viral and host factors during HIV infection, we analyzed the effect of viral mutations on T cell responses in seropositive, asymptomatic HLA-A2+ individuals using four envelope (env)-specific peptides with the HLA-A*0201 binding motif. We showed that the natural sequence variation was frequent within epitopes located in the C-terminal region of the env glycoprotein and was...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.