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Article

Identification of Protective Lassa Virus Epitopes That Are Restricted by HLA-A2

15 Aug 2006

Abstract excerpt

Recovery from Lassa virus (LASV) infection usually precedes the appearance of neutralizing antibodies, indicating that cellular immunity plays a primary role in viral clearance. To date, the role of LASV-specific CD8(+) T cells has not been evaluated in humans. To facilitate such studies, we utilized a predictive algorithm to identify candidate HLA-A2 supertype epitopes from the LASV nucleoprotein and...

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PMID: 16912286
DOI: 10.1128/jvi.00896-06

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