Article
Rare microsatellite polymorphisms in the DNA repair genes XRCC1, XRCC3 and XRCC5 associated with cancer in patients of varying radiosensitivity.
Somatic cell and molecular genetics - 1 Jul 1997
Price E A, Bourne S L, Radbourne R, Lawton P A, Lamerdin J, Thompson L H, Arrand J E
Abstract excerpt
DNA repair defects might contribute both to cancer progression and to the extreme reactions to radiotherapy observed in approximately 5% of patients. Polymorphic microsatellites in three DNA repair genes, XRCC1, XRCC3 and XRCC5, were analyzed for possible linkage to cancer status or clinical radiosensitivity. XRCC1, 3 and 5 proteins are involved in single-strand DNA break rejoining, recombinational repair, and...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.