Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Radiosensitivity of human fibroblasts is associated with amino acid substitution variants in susceptible genes and correlates with the number of risk alleles.

International journal of radiation oncology, biology, physics - 1 May 2007

Alsbeih Ghazi, El-Sebaie Medhat, Al-Harbi Najla, Al-Buhairi Muneera, Al-Hadyan Khaled, Al-Rajhi Nasser

Abstract excerpt

PURPOSE: Genetic predictive markers of radiosensitivity are being sought for stratifying radiotherapy for cancer patients and risk assessment of radiation exposure. We hypothesized that single nucleotide polymorphisms in susceptible genes are associated with, and the number of risk alleles has incremental effect on, individual radiosensitivity. METHODS AND MATERIALS: Six amino acid substitution variants (ATM 1853...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Ataxia Telangiectasia Mutated Proteins
Share to Proto-Oncogene Proteins p21(ras)

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Radiation Dosage

Share to Radiation Tolerance

Share to Transforming Growth Factor beta

Share to Tumor Stem Cell Assay

Share to Tumor Suppressor Proteins

Share to X-ray Repair Cross Complementing Protein 1

Source

Identifiers

PMID: 17331670
DOI: 10.1016/j.ijrobp.2006.12.050

Genes

ATM
XRCC3
XRCC1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Radiosensitivity of human fibroblasts is associated with amino acid substitution variants in susceptible genes and correlates with the number of risk alleles.PMID 17331670Read ↗

Association between TP53 codon 72 single-nucleotide polymorphism and radiation sensitivity of human fibroblasts.Semantic proximity Read ↗

Gender bias in individual radiosensitivity and the association with genetic polymorphic variations.Semantic proximity Read ↗

Prediction of normal tissue radiosensitivity from polymorphisms in candidate genes.Semantic proximity Read ↗

Radiogenomics: the promise of personalized treatment in radiation oncology?Semantic proximity Read ↗

Polymorphisms in double strand break repair related genes influence radiosensitivity phenotype in lymphocytes from healthy individuals.Semantic proximity Read ↗

Single nucleotide polymorphisms of DNA repair genes as predictors of radioresponse.Semantic proximity Read ↗

A quantitative overview of radiosensitivity of human tumor cells across histological type and TP53 statusSemantic proximity Read ↗

Genetic susceptibility to radiation.Semantic proximity Read ↗

Association of single nucleotide polymorphisms in ATM, GSTP1, SOD2, TGFB1, XPD and XRCC1 with clinical and cellular radiosensitivity.Semantic proximity Read ↗

Can risk of radiotherapy-induced normal tissue complications be predicted from genetic profiles?Semantic proximity Read ↗

Tumor response to radiotherapy is dependent on genotype-associated mechanisms in vitro and in vivo.Semantic proximity Read ↗

Association between SNPs in defined functional pathways and risk of early or late toxicity as well as individual radiosensitivity.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.