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Article

Single nucleotide polymorphisms, apoptosis, and the development of severe late adverse effects after radiotherapy.

Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Oct 2008

Azria David, Ozsahin Mahmut, Kramar Andrew, Peters Sheila, Atencio David P, Crompton Nigel E A, Mornex Françoise, Pèlegrin André, Dubois Jean-Bernard, Mirimanoff René-Olivier, Rosenstein Barry S

Abstract excerpt

PURPOSE: Evidence has accumulated in recent years suggestive of a genetic basis for a susceptibility to the development of radiation injury after cancer radiotherapy. The purpose of this study was to assess whether patients with severe radiation-induced sequelae (RIS; i.e., National Cancer Institute/CTCv3.0 grade, > or =3) display both a low capacity of radiation-induced CD8 lymphocyte apoptosis (RILA) in vitro...

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Identifiers

PMID: 18829510
DOI: 10.1158/1078-0432.CCR-08-0700
PMCID: PMC2771757

Genes

ATM
RAD21
SOD2
TGFB1
XRCC1
XRCC3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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