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Article

Influence of polymorphisms at loci encoding DNA repair proteins on cancer susceptibility and G2 chromosomal radiosensitivity.

Environmental and molecular mutagenesis - 1 Jan 2007

Wilding Craig S, Curwen Gillian B, Tawn E Janet, Sheng Xiaohua, Winther Jeanette F, Chakraborty Ranajit, Boice John D

Abstract excerpt

Sixteen candidate polymorphisms (13 SNPs and 3 microsatellites) in nine genes from four DNA repair pathways were examined in 83 subjects, comprising 23 survivors of childhood cancer, their 23 partners, and 37 offspring, all of whom had previously been studied for G(2) chromosomal radiosensitivity. Genotype at the Asp148Glu SNP site in the APEX gene of the base excision repair (BER) pathway was associated with...

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Identifiers

PMID: 17177211
DOI: 10.1002/em.20274
PMCID: PMC2730149

Genes

XRCC3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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