Article
Radiation-induced damage to normal tissues after radiotherapy in patients treated for gynecologic tumors: association with single nucleotide polymorphisms in XRCC1, XRCC3, and OGG1 genes and in vitro chromosomal radiosensitivity in lymphocytes.
International journal of radiation oncology, biology, physics - 15 Jul 2005
De Ruyck Kim, Van Eijkeren Marc, Claes Kathleen, Morthier Rudy, De Paepe Anne, Vral Anne, De Ridder Leo, Thierens Hubert
Abstract excerpt
PURPOSE: To examine the association of polymorphisms in XRCC1 (194Arg/Trp, 280Arg/His, 399Arg/Gln, 632Gln/Gln), XRCC3 (5' UTR 4.541A>G, IVS5-14 17.893A>G, 241Thr/Met), and OGG1 (326Ser/Cys) with the development of late radiotherapy (RT) reactions and to assess the correlation between in vitro chromosomal radiosensitivity and clinical radiosensitivity. METHODS AND MATERIALS: Sixty-two women with cervical or...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.