Article
Copresentation of natural HIV-1 agonist and antagonist ligands fails to induce the T cell receptor signaling cascade.
Proceedings of the National Academy of Sciences of the United States of America - 14 Apr 1998
Purbhoo M A, Sewell A K, Klenerman P, Goulder P J, Hilyard K L, Bell J I, Jakobsen B K, Phillips R E
Abstract excerpt
It is not known how human immunodeficiency virus type 1 (HIV-1)-derived antagonist peptides interfere with intracellular activation of cytotoxic T lymphocytes (CTL). We identified Gag epitope variants in HIV-1-infected patients that act as antagonists of CTL responses to unmutated epitopes. We then investigated the effect that presentation of each variant has on the early events of T cell receptor (TCR) signal...
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