Antagonists or altruists: do viral mutants modulate T-cell responses?

Abstract excerpt

The ability of altered peptide ligands (APLs) to modify or downregulate T-cell responses in vitro has generated much interest. Recently, it was proposed that viral variants may contain mutations in cytotoxic T lymphocyte (CTL) epitopes that allow mutual antagonism, and that these combine to downr...

Topics

• Animals
• Antigens, Viral
• Epitopes
• Genetic Variation
• Humans
• Models, Biological
• Mutation
• T-Lymphocytes, Cytotoxic
• Viral Proteins
• Viruses