Positive selection of low responsive, potentially autoreactive T cells induced by high avidity, non-deleting interactions.

doi:10.1093/intimm/10.7.999

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Article

Positive selection of low responsive, potentially autoreactive T cells induced by high avidity, non-deleting interactions.

International immunology - 1 Jul 1998

Chidgey A P, Boyd R L

Abstract excerpt

Using a novel cell suspension model we investigated the relative abilities of nominal peptide and variants thereof to modulate de novo positive selection of lymphocytic choriomeningitis virus (LCMV)-specific TCR transgenic T cells. Confirming our earlier findings intermediate concentrations (10(-...

Topics

Acetyltransferases
Animals
CD8-Positive T-Lymphocytes
Coculture Techniques
Dimerization
Down-Regulation
Lymphocyte Activation
Mice
Mice, Inbred C57BL
Mice, Transgenic
Phenotype
Proteins
Receptors, Antigen, T-Cell
Receptors, Antigen, T-Cell, alpha-beta
Signal Transduction
T-Lymphocytes

Source

Open in PubMed

Identifiers

PMID: 9701038
DOI: 10.1093/intimm/10.7.999

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9701038-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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