Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Positive selection of low responsive, potentially autoreactive T cells induced by high avidity, non-deleting interactions.

International immunology - 1 Jul 1998

Chidgey A P, Boyd R L

Abstract excerpt

Using a novel cell suspension model we investigated the relative abilities of nominal peptide and variants thereof to modulate de novo positive selection of lymphocytic choriomeningitis virus (LCMV)-specific TCR transgenic T cells. Confirming our earlier findings intermediate concentrations (10(-7) to 10(-5) M) of the nominal agonist peptide, p33, induced CD8 co-receptor down-modulation at the level of the entire...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Lymphocyte Activation
Share to Mice
Share to Mice, Inbred C57BL

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Mice, Transgenic

Share to Phenotype

Share to Proteins

Share to Signal Transduction

Share to T-Lymphocytes

Source

Identifiers

PMID: 9701038
DOI: 10.1093/intimm/10.7.999

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Positive selection of low responsive, potentially autoreactive T cells induced by high avidity, non-deleting interactions.PMID 9701038Read ↗

Lower receptor avidity required for thymic clonal deletion than for effector T-cell function.Semantic proximity Read ↗

Peptide-major histocompatibility complex class II complexes with mixed agonist/antagonist properties provide evidence for ligand-related differences in T cell receptor-dependent intracellular signaling.Semantic proximity Read ↗

Differential T cell signaling induced by antagonist peptide-MHC complexes and the associated phenotypic responses.Semantic proximity Read ↗

Tuning T cell activation threshold and effector function with cross-reactive peptide ligands.Semantic proximity Read ↗

Phenotypic model for early T-cell activation displaying sensitivity, specificity, and antagonism.Semantic proximity Read ↗

Viral Escape Mutant Epitope Maintains TCR Affinity for Antigen yet Curtails CD8 T Cell Responses.Semantic proximity Read ↗

Editing autoreactive TCR enables efficient positive selection.Semantic proximity Read ↗

CD8+ T cell activation is governed by TCR-peptide/MHC affinity, not dissociation rate.Semantic proximity Read ↗

Phenotypic changes accompanying positive selection of CD4+CD8+ thymocytes.Semantic proximity Read ↗

Negative selection, not receptor editing, is a physiological response of autoreactive thymocytes.Semantic proximity Read ↗

Interactions between double positive thymocytes and high affinity ligands presented by cortical epithelial cells generate double negative thymocytes with T cell regulatory activity.Semantic proximity Read ↗

A unique unresponsive CD4+ T cell phenotype post TCR antagonism.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.