Article
Cytotoxic T-cell activity antagonized by naturally occurring HIV-1 Gag variants.
Nature - 2 Jun 1994
Klenerman P, Rowland-Jones S, McAdam S, Edwards J, Daenke S, Lalloo D, Köppe B, Rosenberg W, Boyd D, Edwards A
Abstract excerpt
Most asymptomatic individuals infected with HIV-1 have a cytotoxic T lymphocyte (CTL) response to the virus Gag proteins which can be demonstrated in vitro. Epitopes have been mapped in p17 Gag and p24 Gag restricted by HLA-B8 (p17-3 and p24-13) and -B27 (p24-14). Viruses isolated from patients w...
Topics
- Amino Acid Sequence
- Cell Line
- Epitopes
- Gene Products, gag
- Genetic Variation
- HIV Antigens
- HIV Core Protein p24
- HIV-1
- HLA-B8 Antigen
- Humans
- Molecular Sequence Data
- Peptide Fragments
- Receptors, Antigen, T-Cell
- Recombinant Proteins
- T-Lymphocytes, Cytotoxic
- Vaccinia virus
- Viral Proteins
- gag Gene Products, Human Immunodeficiency Virus