Article
Single T cell receptor-mediated recognition of an identical HIV-derived peptide presented by multiple HLA class I molecules.
Journal of immunology (Baltimore, Md. : 1950) - 1 Nov 2002
Ueno Takamasa, Tomiyama Hiroko, Takiguchi Masafumi
Abstract excerpt
A dual specific human CTL clone harboring one beta and two inframe alpha transcripts of TCR was previously reported to recognize an HIV Pol-derived nonapeptide (IPLTEEAEL) endogenously presented by both syngeneic HLA-B*3501 and HLA-B*5101. In the current study, a retrovirus-mediated TCR transfer of individual alpha- and beta-chains to TCR-negative hybridoma showed that Valpha12.1 TCR in complex with Vbeta5.6 were...
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