Article
The alpha-factor mating pheromone of Saccharomyces cerevisiae: a model for studying the interaction of peptide hormones and G protein-coupled receptors.
Peptides - 1 Sept 2004
Naider Fred, Becker Jeffrey M
Abstract excerpt
Mating in Saccharomyces cerevisiae is initiated by the secretion of diffusible peptide pheromones that are recognized by G protein-coupled receptors (GPCR). This review summarizes the use of the alpha-factor (WHWLQLKPGQPMY)--GPCR (Ste2p) interaction as a paradigm to understand the recognition between medium-sized peptide hormones and their cognate receptors. Studies over the past 15 years have indicated that the...
Topics
- Alanine
- Binding Sites
- Binding, Competitive
- Dose-Response Relationship, Drug
- Fungal Proteins
- Genes, Fungal
- Glycosylation
- Iodine
- Kinetics
- Ligands
- Light
- Models, Chemical
- Models, Molecular
- Mutation