Article
Dominant-negative mutations in the G-protein-coupled alpha-factor receptor map to the extracellular ends of the transmembrane segments.
Molecular and cellular biology - 1 Oct 1998
Dosil M, Giot L, Davis C, Konopka J B
Abstract excerpt
G-protein-coupled receptors (GPCRs) transduce the signals for a wide range of hormonal and sensory stimuli by activating a heterotrimeric guanine nucleotide-binding protein (G protein). The analysis of loss-of-function and constitutively active receptor mutants has helped to reveal the functional...
Topics
- Amino Acid Sequence
- Binding Sites
- Extracellular Space
- GTP-Binding Proteins
- Gene Dosage
- Mating Factor
- Molecular Sequence Data
- Mutation
- Peptides
- Pheromones
- Receptors, Mating Factor
- Receptors, Peptide
- Saccharomyces cerevisiae
- Subcellular Fractions
- Transcription Factors