Mouse embryos lacking Smad1 signals display defects in extra-embryonic tissues and germ cell formation.

doi:10.1242/dev.128.18.3609

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Article

Mouse embryos lacking Smad1 signals display defects in extra-embryonic tissues and germ cell formation.

Development (Cambridge, England) - 1 Sept 2001

Tremblay K D, Dunn N R, Robertson E J

Abstract excerpt

The Smad proteins are important intracellular mediators of the transforming growth factor beta (TGFbeta) family of secreted growth factors. Smad1 is an effector of signals provided by the bone morphogenetic protein (BMP) sub-group of TGFbeta molecules. To understand the role of Smad1 in mouse development, we have generated a Smad1 loss-of-function allele using homologous recombination in ES cells. Smad1-/-...

Topics

Animals
Bone Morphogenetic Proteins
Cell Differentiation
Cell Lineage
Crosses, Genetic
DNA-Binding Proteins
Ectoderm
Embryonic and Fetal Development
Extraembryonic Membranes
Gastrula
Genes, Lethal
Genotype
Germ Cells
Heterozygote
Mesoderm
Mice
Mice, Mutant Strains
Phenotype

Source

Open in PubMed

Identifiers

PMID: 11566864
DOI: 10.1242/dev.128.18.3609

Provenance

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