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Article

Differential requirements for Smad4 in TGFbeta-dependent patterning of the early mouse embryo.

Development (Cambridge, England) - 1 Aug 2004

Chu Gerald C, Dunn N Ray, Anderson Dorian C, Oxburgh Leif, Robertson Elizabeth J

Abstract excerpt

Genetic and biochemical data have identified Smad4 as a key intracellular effector of the transforming growth factor beta (TGFbeta superfamily of secreted ligands. In mouse, Smad4-null embryos do not gastrulate, a phenotype consistent with loss of other TGFbeta-related signaling components. Chimeric analysis reveals a primary requirement for Smad4 in the extra-embryonic lineages; however, within the embryo...

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Identifiers

PMID: 15215210
DOI: 10.1242/dev.01248

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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