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Article

Smad5 knockout mice die at mid-gestation due to multiple embryonic and extraembryonic defects

15 Apr 1999

Abstract excerpt

Smad5 has been implicated as a downstream signal mediator for several bone morphogenetic proteins (BMPs). To understand the in vivo function of Smad5, we generated mice deficient in Smad5 using embryonic stem (ES) cell technology. Homozygous mutant embryos die between E9.5 and E11.5, and display variable phenotypes. Morphological defects are first detected at E8.0 in the developing amnion, gut and heart (the...

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PMID: 10079226
DOI: 10.1242/dev.126.8.1631

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