Article
Multiple roles for activin-like kinase-2 signaling during mouse embryogenesis.
Developmental biology - 15 Sept 1999
Mishina Y, Crombie R, Bradley A, Behringer R R
Abstract excerpt
The members of the transforming growth factor-beta (TGF-beta) superfamily are secreted proteins that interact with cell-surface receptors to elicit signals that regulate a variety of biological processes during vertebrate embryogenesis. Alk2, also known as ActRIA, Tsk7L, and SKR1, encodes a type I TGF-beta family receptor for activins and BMP-7. Initially, Alk2 transcripts are detected in the visceral endoderm of...
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