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Article

Negative control of Smad activity by ectodermin/Tif1gamma patterns the mammalian embryo.

Development (Cambridge, England) - 1 Aug 2010

Morsut Leonardo, Yan Kai-Ping, Enzo Elena, Aragona Mariaceleste, Soligo Sandra M, Wendling Olivia, Mark Manuel, Khetchoumian Konstantin, Bressan Giorgio, Chambon Pierre, Dupont Sirio, Losson Régine, Piccolo Stefano

Abstract excerpt

The definition of embryonic potency and induction of specific cell fates are intimately linked to the tight control over TGFbeta signaling. Although extracellular regulation of ligand availability has received considerable attention in recent years, surprisingly little is known about the intracellular factors that negatively control Smad activity in mammalian tissues. By means of genetic ablation, we show that...

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Identifiers

PMID: 20573697
DOI: 10.1242/dev.053801

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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