Article
Increased transversions in a novel mutator colon cancer cell line.
Oncogene - 5 Mar 1998
Eshleman J R, Donover P S, Littman S J, Swinler S E, Li G M, Lutterbaugh J D, Willson J K, Modrich P, Sedwick W D, Markowitz S D, Veigl M L
Abstract excerpt
We describe a novel mutator phenotype in the Vaco411 colon cancer cell line which increases the spontaneous mutation rate 10-100-fold over background. This mutator results primarily in transversion base substitutions which are found infrequently in repair competent cells. Of the four possible types of transversions, only three were principally recovered. Spontaneous mutations recovered also included transitions...
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