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Article

Molecular analysis of mutations in mutator colorectal carcinoma cell lines.

Human molecular genetics - 1 Nov 1995

Bhattacharyya N P, Ganesh A, Phear G, Richards B, Skandalis A, Meuth M

Abstract excerpt

The nature of mutations occurring in two colorectal carcinoma cell lines deficient in mismatch repair and displaying mutator phenotypes was determined. One of the lines (HCT116) exhibited a higher level of microsatellite instability than the second (DLD-1), although the rate of mutation at the selectable locus encoding the purine salvage enzyme hypoxanthine guanine phosphoribosyl transferase (HPRT) was equally...

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Identifiers

PMID: 8589681
DOI: 10.1093/hmg/4.11.2057

Genes

DLD

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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