Article
Molecular analysis of mutations in mutator colorectal carcinoma cell lines.
Human molecular genetics - 1 Nov 1995
Bhattacharyya N P, Ganesh A, Phear G, Richards B, Skandalis A, Meuth M
Abstract excerpt
The nature of mutations occurring in two colorectal carcinoma cell lines deficient in mismatch repair and displaying mutator phenotypes was determined. One of the lines (HCT116) exhibited a higher level of microsatellite instability than the second (DLD-1), although the rate of mutation at the se...
Topics
- Base Sequence
- Colorectal Neoplasms
- DNA, Neoplasm
- DNA, Satellite
- Humans
- Hypoxanthine Phosphoribosyltransferase
- Molecular Sequence Data
- Mutation
- Tumor Cells, Cultured