Article
Hypermutability and mismatch repair deficiency in RER+ tumor cells.
Cell - 17 Dec 1993
Parsons R, Li G M, Longley M J, Fang W H, Papadopoulos N, Jen J, de la Chapelle A, Kinzler K W, Vogelstein B, Modrich P
Abstract excerpt
A subset of sporadic colorectal tumors and most tumors developing in hereditary nonpolyposis colorectal cancer patients display frequent alterations in microsatellite sequences. Such tumors have been thought to manifest replication errors (RER+), but the basis for the alterations has remained conjectural. We demonstrate that the mutation rate of (CA)n repeats in RER+ tumor cells is at least 100-fold that in RER-...
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