Article
Expression of mutant alanine tRNAs increases spontaneous mutagenesis in Escherichia coli.
Molecular microbiology - 1 Apr 2002
Dorazi Robert, Lingutla Josephine J, Humayun M Zafri
Abstract excerpt
The expression of mutA, an allele of the glycine tRNA gene glyV, can confer a novel mutator phenotype that correlates with its ability to promote Asp-->Gly mistranslation. Both activities are mediated by a single base change within the anticodon such that the mutant tRNA can decode aspartate codons (GAC/U) instead of the normal glycine codons (GCC/U). Here, we investigate whether specific Asp-->Gly mistranslation...
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