Article
Mutator phenotypes in human colorectal carcinoma cell lines.
Proceedings of the National Academy of Sciences of the United States of America - 5 Jul 1994
Bhattacharyya N P, Skandalis A, Ganesh A, Groden J, Meuth M
Abstract excerpt
Recent studies have revealed that tumors in patients with hereditary nonpolyposis colon cancer are associated with high-frequency alterations of microsatellite sequences. To investigate the mechanisms and consequences of this form of genetic instability, we identified three colorectal carcinoma c...
Topics
- Cell Line
- Colorectal Neoplasms
- Colorectal Neoplasms, Hereditary Nonpolyposis
- DNA, Neoplasm
- DNA, Satellite
- Genetic Markers
- Humans
- Hypoxanthine Phosphoribosyltransferase
- Mutagenesis
- Mutation
- Ouabain
- Repetitive Sequences, Nucleic Acid
- Thioguanine
- Tumor Cells, Cultured