Article
Mutator phenotypes in human colorectal carcinoma cell lines.
Proceedings of the National Academy of Sciences of the United States of America - 5 Jul 1994
Bhattacharyya N P, Skandalis A, Ganesh A, Groden J, Meuth M
Abstract excerpt
Recent studies have revealed that tumors in patients with hereditary nonpolyposis colon cancer are associated with high-frequency alterations of microsatellite sequences. To investigate the mechanisms and consequences of this form of genetic instability, we identified three colorectal carcinoma cell lines that express dinucleotide-repeat instability like that found in hereditary nonpolyposis colon cancer tumors...
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