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Article

Cancer cells exhibit a mutator phenotype.

Advances in cancer research - 1 Jan 1998

Loeb L A

Abstract excerpt

This review analyzes the concept and evidence in support of a mutator phenotype in human cancer. The large number of mutations reported in tumor cells cannot be accounted for by the low mutation rates observed in normal somatic cells; rather, it must be a manifestation of a mutator phenotype present early during the tumorigenic process. The interaction between increased mutagenesis and clonal selection provides a...

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PMID: 9338073
DOI: 10.1016/s0065-230x(08)60699-5

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Source receipt: pubmed, retrieved 7 Sept 2026.

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