Article
Specificity of spontaneous mutations induced in mutA mutator cells.
Mutation research - 14 Apr 2004
Balashov Sergey, Humayun M Zafri
Abstract excerpt
Escherichia coli cells expressing the mutA allele of a glyV (glycine tRNA) gene express a strong mutator phenotype. The mutA allele differs from the wild type glyV gene by a base substitution in the anticodon such that the resulting tRNA misreads certain aspartate codons as glycine, resulting in random, low-level Asp-->Gly substitutions in proteins. Subsequent work showed that many types of mistranslation can...
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