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Article

The spectrum of spontaneous mutations in a Saccharomyces cerevisiae uracil-DNA-glycosylase mutant limits the function of this enzyme to cytosine deamination repair.

Journal of bacteriology - 1 Nov 1991

Impellizzeri K J, Anderson B, Burgers P M

Abstract excerpt

Uracil-DNA-glycosylase has been proposed to function as the first enzyme in strand-directed mismatch repair in eukaryotic organisms, through removal of uracil from dUMP residues periodically inserted into the DNA during DNA replication (Aprelikova, O. N., V. M. Golubovskaya, T. A. Kusmin, and N. V. Tomilin, Mutat. Res. 213:135-140, 1989). This hypothesis was investigated with Saccharomyces cerevisiae. Mutation...

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Identifiers

PMID: 1938887
DOI: 10.1128/jb.173.21.6807-6810.1991
PMCID: PMC209031

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Source receipt: pubmed, retrieved 7 Sept 2026.

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