The spectrum of spontaneous mutations in a Saccharomyces cerevisiae uracil-DNA-glycosylase mutant limits the function of this enzyme to cytosine deamination repair.

doi:10.1128/jb.173.21.6807-6810.1991

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Article

The spectrum of spontaneous mutations in a Saccharomyces cerevisiae uracil-DNA-glycosylase mutant limits the function of this enzyme to cytosine deamination repair.

Journal of bacteriology - 1 Nov 1991

Impellizzeri K J, Anderson B, Burgers P M

Abstract excerpt

Uracil-DNA-glycosylase has been proposed to function as the first enzyme in strand-directed mismatch repair in eukaryotic organisms, through removal of uracil from dUMP residues periodically inserted into the DNA during DNA replication (Aprelikova, O. N., V. M. Golubovskaya, T. A. Kusmin, and N....

Topics

Base Sequence
Cytosine
DNA Glycosylases
DNA Repair
DNA, Fungal
Molecular Sequence Data
Mutation
N-Glycosyl Hydrolases
Saccharomyces cerevisiae
Uracil-DNA Glycosidase

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