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Metabolic cytochrome P450 genotypes and assessment of individual susceptibility to lung cancer.

Pharmacogenetics - 1 Dec 1992

Hirvonen A, Husgafvel-Pursiainen K, Anttila S, Karjalainen A, Sorsa M, Vainio H

Abstract excerpt

Three polymorphic cytochrome P450 genes that have attracted interest for their potential role in human pulmonary carcinogenesis, i.e. CYP1A1, CYP2D6 and CYP2E1, were studied in a population consisting of 106 lung cancer patients and 122 healthy controls. Polymorphism of the CYP2D6 gene encoding for debrisoquine hydroxylase was determined using XbaI restriction fragment length polymorphism (RFLP) analysis together...

Topics

Cytochrome P-450 CYP1A1
Cytochrome P-450 CYP2D6
Cytochrome P-450 Enzyme System
Female
Genotype
Humans
Lung Neoplasms
Male
Mixed Function Oxygenases
Oxidoreductases
Polymorphism, Genetic

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Identifiers

PMID: 1306126
DOI: 10.1097/00008571-199212000-00003

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1306126-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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