Article
Human debrisoquine hydroxylase gene polymorphisms in cancer patients and controls.
Carcinogenesis - 1 Sept 1990
Sugimura H, Caporaso N E, Shaw G L, Modali R V, Gonzalez F J, Hoover R N, Resau J H, Trump B F, Weston A, Harris C C
Abstract excerpt
The extensive metabolizer phenotype of debrisoquine has been associated with increased risk of lung cancer, and it has been proposed that a molecular test for this phenotype is feasible. DNA restriction fragment length polymorphisms of the human debrisoquine 4-hydroxylase gene locus (CYP2D6), and...
Topics
- Adenocarcinoma
- Carcinoma, Small Cell
- Carcinoma, Squamous Cell
- Cytochrome P-450 CYP2D6
- Cytochrome P-450 Enzyme System
- Debrisoquin
- Deoxyribonuclease EcoRI
- Deoxyribonucleases, Type II Site-Specific
- Female
- Genes
- Humans
- Lung Diseases, Obstructive
- Lung Neoplasms
- Male
- Mixed Function Oxygenases