Article
Human debrisoquine hydroxylase gene polymorphisms in cancer patients and controls.
Carcinogenesis - 1 Sept 1990
Sugimura H, Caporaso N E, Shaw G L, Modali R V, Gonzalez F J, Hoover R N, Resau J H, Trump B F, Weston A, Harris C C
Abstract excerpt
The extensive metabolizer phenotype of debrisoquine has been associated with increased risk of lung cancer, and it has been proposed that a molecular test for this phenotype is feasible. DNA restriction fragment length polymorphisms of the human debrisoquine 4-hydroxylase gene locus (CYP2D6), and the metabolic phenotype for debrisoquine have been studied in a group of healthy volunteers, a group of lung cancer...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.