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Article

Identification of the primary gene defect at the cytochrome P450 CYP2D locus.

Nature - 25 Oct 1990

Gough A C, Miles J S, Spurr N K, Moss J E, Gaedigk A, Eichelbaum M, Wolf C R

Abstract excerpt

The mammalian cytochrome P450-dependent monooxygenase system is involved in the metabolism of drugs and chemical carcinogens. The role of these enzymes in toxicological response is exemplified by an autosomal recessive polymorphism at the cytochrome P450 CYP2D6 debrisoquine hydroxylase locus which results in the severely compromised metabolism of at least 25 drugs, and which in some cases can lead to...

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PMID: 1978251
DOI: 10.1038/347773a0

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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Identification of the primary gene defect at the cytochrome P450 CYP2D locus.PMID 1978251Read ↗

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