Article
Identification of the primary gene defect at the cytochrome P450 CYP2D locus.
Nature - 25 Oct 1990
Gough A C, Miles J S, Spurr N K, Moss J E, Gaedigk A, Eichelbaum M, Wolf C R
Abstract excerpt
The mammalian cytochrome P450-dependent monooxygenase system is involved in the metabolism of drugs and chemical carcinogens. The role of these enzymes in toxicological response is exemplified by an autosomal recessive polymorphism at the cytochrome P450 CYP2D6 debrisoquine hydroxylase locus which results in the severely compromised metabolism of at least 25 drugs, and which in some cases can lead to...
Topics
- Base Sequence
- Cytochrome P-450 CYP2D6
- Cytochrome P-450 Enzyme System
- Deoxyribonucleases, Type II Site-Specific
- Humans
- Lung Neoplasms
- Mixed Function Oxygenases
- Molecular Sequence Data
- Mutation
- Phenotype
- Polymerase Chain Reaction