CYP2D6 genes and risk of liver cancer.

doi:10.1016/s0140-6736(95)92965-7

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Article

CYP2D6 genes and risk of liver cancer.

Lancet (London, England) - 1 Apr 1995

Agúndez J A, Ledesma M C, Benítez J, Ladero J M, Rodríguez-Lescure A, Díaz-Rubio E, Díaz-Rubio M

Abstract excerpt

We have studied by use of PCR and XbaI and EcoRI restriction-fragment-length polymorphism whether mutations at the polymorphic CYP2D6 (debrisoquine hydroxylase) gene locus are associated with liver cancer. The frequency of CYP2D6 genes containing inactivating mutations was lower among 75 liver ca...

Topics

Aged
Alleles
Cytochrome P-450 CYP2D6
Cytochrome P-450 Enzyme System
Genotype
Humans
Liver Neoplasms
Middle Aged
Mixed Function Oxygenases
Mutation
Polymerase Chain Reaction
Polymorphism, Restriction Fragment Length
Risk

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