Article
Polymorphism in CYP1A1 and CYP2D6 genes: possible association with susceptibility to lung cancer.
Environmental health perspectives - 1 Oct 1993
Hirvonen A, Husgafvel-Pursiainen K, Anttila S, Karjalainen A, Vainio H
Abstract excerpt
Polymorphism of CYP2D6 gene encoding for debrisoquine hydroxylase was determined genotypically for 94 controls and 77 lung cancer patients using a polymerase chain reaction-based application. Both of the point mutations that give rise to deficient alleles of the CYP2D6 gene are detectable by this...
Topics
- Alleles
- Cytochrome P-450 Enzyme System
- Disease Susceptibility
- Female
- Genetic Variation
- Genotype
- Humans
- Leukocytes
- Lung Neoplasms
- Male
- Polymerase Chain Reaction
- Polymorphism, Genetic
- Polymorphism, Restriction Fragment Length