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Article

NF-kappaB-inducing kinase activates IKK-alpha by phosphorylation of Ser-176.

Proceedings of the National Academy of Sciences of the United States of America - 31 Mar 1998

Ling L, Cao Z, Goeddel D V

Abstract excerpt

Activation of the transcription factor NF-kappaB by inflammatory cytokines involves the successive action of NF-kappaB-inducing kinase (NIK) and two IkappaB kinases, IKK-alpha and IKK-beta. Here we show that NIK preferentially phosphorylates IKK-alpha over IKK-beta, leading to the activation of IKK-alpha kinase activity. This phosphorylation of IKK-alpha occurs specifically on Ser-176 in the activation loop...

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Identifiers

PMID: 9520446
DOI: 10.1073/pnas.95.7.3792
PMCID: PMC19916

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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