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Article

Tyrosine phosphorylation is required for IkappaB kinase-beta (IKKbeta) activation and function in osteoclastogenesis.

The Journal of biological chemistry - 13 Aug 2010

Darwech Isra, Otero Jesse E, Alhawagri Muhammad A, Abu-Amer Yousef

Abstract excerpt

The transcription factor NF-kappaB is crucial for numerous cellular functions such as survival, differentiation, immunity, and inflammation. A key function of this family of transcription factors is regulation of osteoclast differentiation and function, which in turn controls skeletal homeostasis...

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Identifiers

PMID: 20534585
DOI: 10.1074/jbc.M110.121533
PMCID: PMC2919116

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20534585-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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Tyrosine phosphorylation is required for IkappaB kinase-beta (IKKbeta) activation and function in osteoclastogenesis.PMID 20534585Read ↗

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