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Article

Functional interplay between acetylation and methylation of the RelA subunit of NF-kappaB.

Molecular and cellular biology - 1 May 2010

Yang Xiao-Dong, Tajkhorshid Emad, Chen Lin-Feng

Abstract excerpt

Posttranslational modifications of the RelA subunit of NF-kappaB, including acetylation and methylation, play a key role in controlling the strength and duration of its nuclear activity. Whether these modifications are functionally linked is largely unknown. Here, we show that the acetylation of lysine 310 of RelA impairs the Set9-mediated methylation of lysines 314 and 315, which is important for the...

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Share to Acetylation
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Share to Histone-Lysine N-Methyltransferase

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 20160011
DOI: 10.1128/MCB.01343-09
PMCID: PMC2863596

Genes

SET
SIRT1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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